Chromosomal aberrations and oxidative DNA adduct 8-hydroxy-2-deoxyguanosine as biomarkers of radiotoxicity in radiation workers
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چکیده
منابع مشابه
Effects of UV Radiation and Oxidative DNA Adduct 8-hydroxy-2’-deoxiguanosine on the Skin Diseases
Excessive sun exposure may be associated with increased oxidative stress and oxidative damage of DNA. Based on this hypothesis, the authors focused on investigating the causal role of UV-induced genomic damage in the pathophysiology of porphyria cutaneatarda (photosensitive acquired metabolic disorder with autosomal dominanttransmittion). In this study we demonstrated that serum levels of 8-hyd...
متن کاملUrinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
DNA is subject to constant oxidative damage from endogenous oxidants. The oxidized DNA is continuously repaired and the oxidized bases are excreted in the urine. A simple routine analytical procedure is described for urinary 8-hydroxy-2'-deoxyguanosine, an oxidative DNA damage adduct, as an indicator of oxidative damage in humans and rodents. This adduct was purified from human urine and charac...
متن کاملUrinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage in workers exposed to fine particulates.
Residual oil fly ash (ROFA) is a chemically complex mixture of compounds, including metals that are potentially carcinogenic because of their ability to cause oxidative injury. In this study, we investigated the association between exposure to particulate matter with an aerodynamic mass median diameter <or= 2.5 micro m (PM2.5) and oxidative DNA damage and repair, as indicated by urinary 8-hydro...
متن کاملurinary 8-hydroxy-deoxyguanosine as a biomarker of oxidative dna damage in employees of subway system.
exposure to air pollutants, steel dust or other occupational and environmental hazards as oxidative stress have adverse effects on subway workers' health. oxidative stress generates an excessive amount of reactive oxygen species (ros) and oxygen free radicals during their work time in the tunnels. once dna is repaired, urinary 8-hydroxy-deoxyguanosine (8-ohdg) is excreted in the urine. therefor...
متن کاملOxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.
Oxidative damage to DNA is shown to be extensive and could be a major cause of the physiological changes associated with aging and the degenerative diseases related to aging such as cancer. The oxidized nucleoside, 8-hydroxy-2'-deoxyguanosine (oh8dG), one of the approximately 20 known oxidative DNA damage products, has been measured in DNA isolated from various organs of Fischer 344 rats of dif...
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ژورنال
عنوان ژورنال: Journal of Radiation Research and Applied Sciences
سال: 2016
ISSN: 1687-8507
DOI: 10.1016/j.jrras.2015.12.004